Reymond Research Group

University of Bern

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Our paper Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase is published in Nature Chemical Biology! Abstract: C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins involved in cellular communication processes. The tryptophan C-mannosyltransferase (CMT) enzymes that install the modification attach a mannose to
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An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening

An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening

Our paper An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening is published in Cell Reports Physical Science! Highlights: • Stereorandomized antimicrobial peptide dendrimers are identified by virtual screening • A switch to L residues induces α-helical folding and strong toxicity in one sr-AMPD • Another AMPD remains intrinsically disordered, active, and
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Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Our paper Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening is now published online in RSC Chemical Science! This work reports the use of in-house built 3D (xLOS) and 2D (Xfp) ligand based virtual screeining approaches (LBVS) for the
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